Embryologic Development and Defects · USMLE Step 1

A fetus has polyhydramnios. Ultrasound reveals esophageal atresia. This condition is most directly caused by abnormal development of which structure?

  1. Tracheoesophageal septum
  2. Laryngotracheal groove
  3. Bronchial buds
  4. Pharyngeal pouches
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Correct answer: Tracheoesophageal septum

Abnormal partitioning of the esophagus and trachea by the tracheoesophageal septum causes esophageal atresia and tracheoesophageal fistula. Polyhydramnios results from impaired fetal swallowing.

Difficulty: Medium Question 4 of 20

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