Mitochondrial inheritance · USMLE Step 1

Which of the following statements about recombination in human mitochondrial DNA is most accurate?

  1. mtDNA frequently recombines between maternal and paternal genomes
  2. mtDNA recombines only during meiotic division
  3. mtDNA does not recombine and passes clonally from mother to child
  4. mtDNA recombination gives rise to X-linked traits
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Correct answer: mtDNA does not recombine and passes clonally from mother to child

Human mtDNA is typically transmitted maternally without recombination, so it behaves as a single haploid locus — which aids in tracing maternal lineages.

Difficulty: Medium Question 7 of 19

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