Which of the following features is NOT typical of mitochondrial (mtDNA) inheritance of disease?
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Correct answer: Transmission from affected fathers to children
Transmission of mtDNA mutations from father to child is generally absent because paternal mitochondria are excluded at fertilization; thus father-to-child transmission is not a feature of mitochondrial inheritance.
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More Mitochondrial inheritance questions
- Why does mitochondrial inheritance behave as a single locus rather than following Mendelian segregation rules?
- Which principle explains why rare deleterious mtDNA mutations may be lost in one generation despite being present in the mother?
- Which of the following is a potential challenge when diagnosing mitochondrial diseases using family history alone?
- Which of the following statements about nuclear-encoded mitochondrial proteins and their inheritance is correct?
- Which mitochondrial feature makes mtDNA a useful tool for tracing human maternal ancestry over many generations?
- Which of the following would be strong evidence for a nuclear (rather than mitochondrial) cause of a suspected mitochondrial disease?