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Gene therapy basics · USMLE Step 1

Which statement about non-viral gene delivery systems is correct compared to viral vectors?

  1. They always integrate the therapeutic gene into the host genome
  2. They typically achieve higher transduction efficiency than viruses
  3. They are less immunogenic but often less efficient and transient
  4. They self-replicate inside the cell just like viral vectors do
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Correct answer: They are less immunogenic but often less efficient and transient

Non-viral methods (e.g. liposomes, electroporation) avoid viral immunogenicity and insertional mutagenesis, but their delivery efficiency is usually lower and expression often transient, limiting effectiveness.

Difficulty: Medium Question 18 of 21

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