Cell Signalling and Receptor Mechanisms · USMLE Step 1

Which receptor class is most likely to mediate rapid synaptic transmission in neurons via direct ion flow upon neurotransmitter binding?

  1. GPCR
  2. Enzyme-linked receptor
  3. Ligand-gated ion channel
  4. Intracellular nuclear receptor
Show answer and explanation

Correct answer: Ligand-gated ion channel

Ligand-gated ion channels open upon neurotransmitter binding, allowing rapid ion movement across membranes — suitable for fast synaptic signaling.

Difficulty: Medium Question 13 of 22

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