Which G protein α-subunit family typically activates phospholipase C, leading to generation of IP₃ and DAG?
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Correct answer: Gα_q/11
Gα_q family subunits activate phospholipase C, which cleaves PIP₂ into IP₃ and DAG; IP₃ then mobilizes Ca²⁺ from intracellular stores and DAG activates protein kinase C.
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