Urine Concentration and Dilution · Physiology

Which factor reduces the kidney's ability to concentrate urine?

  1. Persistently high circulating ADH levels
  2. A fully intact and functional loop of Henle
  3. Reduced medullary blood flow
  4. Damage to the loop of Henle
Show answer and explanation

Correct answer: Damage to the loop of Henle

Damage to the loop of Henle disrupts countercurrent multiplication. This impairs formation of the medullary gradient.

Difficulty: Medium Question 16 of 20

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