Urine Concentration and Dilution · Physiology

Which segment of the nephron is impermeable to water but actively transports sodium chloride?

  1. Proximal convoluted tubule
  2. Descending limb of loop of Henle
  3. Ascending limb of loop of Henle
  4. Collecting duct
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Correct answer: Ascending limb of loop of Henle

The thick ascending limb actively reabsorbs sodium chloride but is impermeable to water. This property is essential for generating the medullary osmotic gradient.

Difficulty: Medium Question 2 of 20

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