Renal pathophysiology · Physiology

Acute kidney injury (AKI) is best defined as:

  1. Slow progressive loss of kidney function over many years
  2. Sudden decline in renal function over hours to days
  3. Reduced urine output with a normal GFR
  4. Irreversible loss of functioning nephrons
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Correct answer: Sudden decline in renal function over hours to days

AKI is characterized by a rapid decrease in glomerular filtration rate occurring over hours to days. It leads to accumulation of nitrogenous wastes and disturbances in fluid and electrolyte balance.

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