Thyroid peroxidase (TPO) is a multifunctional enzyme. Which of the following is NOT a role of TPO?
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Correct answer: Proteolysis of thyroglobulin to release free hormones
TPO is responsible for oxidation, organification, and coupling. The release of free T3 and T4 from thyroglobulin, however, requires endocytosis of the colloid and subsequent proteolysis by lysosomal enzymes.
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