Menstrual Cycle and Spermatogenesis · Physiology

Which enzyme is responsible for the conversion of testosterone to estradiol in both the brain and the ovaries?

  1. 5-alpha reductase
  2. Aromatase (CYP19A1)
  3. 17-beta hydroxysteroid dehydrogenase
  4. Cholesterol side-chain cleavage enzyme
Show answer and explanation

Correct answer: Aromatase (CYP19A1)

Aromatase is the key enzyme that converts androgens (like testosterone) into estrogens (like estradiol). In the ovaries, this occurs in the granulosa cells under the influence of FSH.

Difficulty: Medium Question 29 of 40

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