Adrenal and Pancreas Hormones · Physiology

Which of the following describes the mechanism of action for insulin on its target receptor?

  1. Activation of a G-protein coupled receptor
  2. Stimulation of intrinsic tyrosine kinase activity
  3. Direct binding to an intracellular nuclear receptor
  4. Opening of a ligand-gated ion channel
Show answer and explanation

Correct answer: Stimulation of intrinsic tyrosine kinase activity

The insulin receptor is a transmembrane protein with intrinsic tyrosine kinase activity. Upon insulin binding, the receptor autophosphorylates and triggers a cascade through Insulin Receptor Substrates (IRS).

Difficulty: Medium Question 17 of 40

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