Bronchodilators · Pharmacology

Which statement regarding the therapeutic index of Theophylline is correct?

  1. It has a very wide therapeutic index
  2. Monitoring blood levels is unnecessary
  3. It has a narrow therapeutic index (typically 5-15 mcg/mL)
  4. Toxicity only occurs at levels above 100 mcg/mL
Show answer and explanation

Correct answer: It has a narrow therapeutic index (typically 5-15 mcg/mL)

Theophylline has a narrow therapeutic range. Levels above 20 mcg/mL are frequently associated with adverse effects like nausea, while levels above 30 mcg/mL can cause life-threatening arrhythmias and seizures.

Difficulty: Medium Question 14 of 20

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