Which of the following mechanisms explains why inhaled anticholinergics are particularly effective in COPD?
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Correct answer: Vagal tone is the primary reversible component of airway obstruction in COPD
In COPD, the cholinergic pathway via the vagus nerve is a major contributor to bronchoconstriction. Blocking M3 receptors effectively reduces this resting tone and decreases mucus hypersecretion.
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