What is the primary cellular mechanism of action for Short-Acting Beta-2 Agonists (SABAs) like Albuterol?
Show answer and explanation
Correct answer: Activation of adenylyl cyclase, increasing cAMP
Beta-2 agonists bind to Gs-protein-coupled receptors, which activates adenylyl cyclase. This increases intracellular cyclic AMP (cAMP), leading to protein kinase A activation and subsequent relaxation of bronchial smooth muscle.
Keep practicing
More Bronchodilators questions
- Which of the following bronchodilators is classified as a Long-Acting Muscarinic Antagonist (LAMA)?
- Theophylline achieves bronchodilation primarily through which of the following mechanisms?
- Which side effect is commonly associated with the systemic absorption of inhaled Beta-2 agonists?
- Ipratropium bromide is chemically related to which alkaloid, helping to explain its anticholinergic properties?
- What is the primary clinical indication for Long-Acting Beta-2 Agonists (LABAs) like Salmeterol in asthma management?
- Which enzyme's metabolism is a major concern for Theophylline, leading to numerous drug-drug interactions?