Thiazide Diuretics · Pharmacology

What effect do thiazide diuretics have on magnesium levels?

  1. They cause hypermagnesemia
  2. They cause hypomagnesemia
  3. They have no effect on magnesium
  4. They stimulate magnesium reabsorption in the loop of Henle
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Correct answer: They cause hypomagnesemia

Chronic use of thiazide diuretics can lead to magnesium depletion (hypomagnesemia). This is due to increased magnesium excretion in the distal tubule, though the exact mechanism is less clear than that of potassium loss.

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