Which of the following transport proteins is the primary target inhibited by loop diuretics?
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Correct answer: Na+/K+/2Cl- cotransporter
Loop diuretics act on the thick ascending limb of the loop of Henle by binding to the chloride-binding site of the Na+/K+/2Cl- cotransporter (NKCC2). This prevents the reabsorption of these electrolytes, leading to a significant increase in their excretion.
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More Loop Diuretics questions
- Which of the following is considered the most potent loop diuretic available for clinical use?
- Loop diuretics are known to decrease the reabsorption of which divalent cations by abolishing the lumen-positive transepithelial potential?
- Which loop diuretic would be the most appropriate choice for a patient with a documented severe sulfonamide allergy?
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