Which mechanism describes how many monoclonal antibodies, such as Rituximab, induce the destruction of target cells via NK cells?
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Correct answer: Antibody-dependent cell-mediated cytotoxicity (ADCC)
In ADCC, the Fab region of the antibody binds to the target cell, while the Fc region binds to Fc receptors (CD16) on effector cells like Natural Killer (NK) cells. This triggers the release of perforins and granzymes to lyse the target cell.
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