Muromonab-CD3 (OKT3) was an early biologic that acted by:
Show answer and explanation
Correct answer: Inhibiting the CD3 complex on T-cells
OKT3 was a murine monoclonal antibody that targeted the CD3 epsilon chain on T-cells, causing rapid depletion and internalization of the TCR complex. It is largely discontinued due to severe cytokine release syndrome.
Keep practicing
More Immunosuppressants questions
- Leflunomide is used in Rheumatoid Arthritis to inhibit which metabolic pathway?
- Fingolimod is a first-in-class oral drug for Multiple Sclerosis that works by:
- Abatacept is a fusion protein that inhibits T-cell activation by:
- Which agent is specifically used to prevent Rh isoimmunization in Rh-negative mothers?
- What is the primary risk of using 'Antithymocyte Globulin' (ATG) in transplant patients?
- Which of the following describes the mechanism of Belatacept?