Leflunomide is used in Rheumatoid Arthritis to inhibit which metabolic pathway?
Show answer and explanation
Correct answer: Pyrimidine synthesis (Dihydroorotate dehydrogenase)
Leflunomide's active metabolite inhibits dihydroorotate dehydrogenase. This limits the availability of pyrimidines, which prevents T-cell proliferation without affecting cells that can use salvage pathways.
Keep practicing
More Immunosuppressants questions
- Fingolimod is a first-in-class oral drug for Multiple Sclerosis that works by:
- Abatacept is a fusion protein that inhibits T-cell activation by:
- Which agent is specifically used to prevent Rh isoimmunization in Rh-negative mothers?
- What is the primary risk of using 'Antithymocyte Globulin' (ATG) in transplant patients?
- Which of the following describes the mechanism of Belatacept?
- The use of Mycophenolate Mofetil during pregnancy is associated with: