Abatacept is a fusion protein that inhibits T-cell activation by:
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Correct answer: Binding to CD80/86 to block co-stimulation with CD28
T-cells require two signals for activation: the TCR signal and a co-stimulatory signal (CD28-CD80/86). Abatacept (CTLA4-Ig) binds to CD80/86 on antigen-presenting cells, blocking the second signal.
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