Blood Transfusion Reactions · Pharmacology

Transfusion-related acute lung injury (TRALI) is characterized by:

  1. Pulmonary edema within 6 hours of transfusion
  2. Delayed hemolysis about 7 days after transfusion
  3. Severe hypertension with bradycardia
  4. Iron overload deposited within the liver
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Correct answer: Pulmonary edema within 6 hours of transfusion

TRALI presents as acute non-cardiogenic pulmonary edema within 6 hours of transfusion. It is thought to be caused by donor antibodies reacting with recipient leukocytes. Patients develop hypoxia and bilateral pulmonary infiltrates.

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