Which transfusion reaction is most associated with hypotension and bronchospasm in IgA-deficient patients?
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Correct answer: Excessive volume transfused
Anaphylactic transfusion reactions occur in IgA-deficient patients with anti-IgA antibodies. Exposure to donor IgA can trigger severe IgE-mediated reactions. Symptoms include hypotension, bronchospasm, and shock.
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