Which of the following antiplatelet drugs is a prodrug that requires two-step hepatic activation by CYP450 enzymes, particularly CYP2C19?
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Correct answer: Clopidogrel
Clopidogrel is a thienopyridine prodrug. Its conversion to an active metabolite is heavily dependent on the CYP2C19 enzyme, which is why genetic polymorphisms in this enzyme can lead to reduced antiplatelet efficacy.
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More Antiplatelet Drugs questions
- Unlike Clopidogrel and Prasugrel, Ticagrelor is characterized by which of the following properties?
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- What is the mechanism of action of Dipyridamole when used as an antiplatelet agent?
- Prasugrel is contraindicated in which of the following patient populations due to an increased risk of intracranial hemorrhage?
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- Which side effect is uniquely associated with Ticagrelor therapy and may lead to drug discontinuation?