Antiplatelet Drugs · Pharmacology

Vorapaxar is a newer antiplatelet drug that targets which specific receptor?

  1. P2Y12 ADP receptor
  2. Protease-activated receptor-1 (PAR-1)
  3. COX-2 cyclooxygenase enzyme
  4. Glycoprotein VI platelet collagen receptor
Show answer and explanation

Correct answer: Protease-activated receptor-1 (PAR-1)

Vorapaxar is a competitive antagonist of PAR-1, the primary receptor for thrombin on human platelets. By blocking this pathway, it inhibits thrombin-induced platelet aggregation without affecting thrombin's ability to cleave fibrinogen.

Difficulty: Medium Question 7 of 20

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