Antiplatelet Drugs · Pharmacology

What is the mechanism of action of Dipyridamole when used as an antiplatelet agent?

  1. Inhibition of phosphodiesterase and adenosine uptake
  2. Irreversible covalent blockade of the platelet ADP receptors
  3. Direct inhibition of thrombin protease activity
  4. Activation of the antithrombin III pathway
Show answer and explanation

Correct answer: Inhibition of phosphodiesterase and adenosine uptake

Dipyridamole increases intra-platelet levels of cAMP by inhibiting phosphodiesterase and blocking the cellular uptake of adenosine. Elevated cAMP levels inhibit platelet activation and aggregation.

Difficulty: Medium Question 5 of 20

Practice all 20 Antiplatelet Drugs questions

Keep practicing

More Antiplatelet Drugs questions