A drug that binds to a receptor and produces a submaximal response, even at high concentrations, is known as a:
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Correct answer: Partial agonist
Partial agonists have intrinsic activity greater than zero but less than a full agonist. Even when all receptors are occupied, they cannot elicit the maximal response ($E_{max}$) of the system.
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More Pharmacodynamics questions
- In the presence of a competitive antagonist, how does the log dose-response curve of an agonist change?
- Which of the following describes an 'Inverse Agonist'?
- The 'Therapeutic Index' (TI) of a drug is calculated as the ratio of:
- Which receptor type typically mediates the fastest physiologic responses (millisecond timescale)?
- Which signaling molecule is primarily associated with the activation of the Gq protein pathway?
- Non-competitive antagonists decrease the maximal efficacy ($E_{max}$) of an agonist because: