Half-Life and Clearance · Pharmacology

If the dosing rate of a drug is doubled during a continuous IV infusion, what happens to the steady-state plasma concentration ($Css$)?

The $Css$ is also doubled
The $Css$ remains the same
The $Css$ is quadrupled
The $Css$ is reduced by half

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Correct answer: The $Css$ is also doubled

At steady state, the dosing rate equals the elimination rate ($Dosing Rate = Cl \times Css$). Since clearance is constant in first-order kinetics, doubling the dosing rate directly doubles the steady-state concentration.

Difficulty: Medium Question 9 of 20

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If the dosing rate of a drug is doubled during a continuous IV infusion, what happens to the steady-state plasma concentration ($Css$)?

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