If a drug has a Clearance of 2 L/hr and a Volume of Distribution of 40 L, what is its approximate half-life?
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Correct answer: 14 hours
Using the formula $t_{1/2} = 0.693 \times Vd / Cl$: $t_{1/2} = 0.693 \times (40 / 2) = 0.693 \times 20 \approx 13.86$ hours.
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