If a drug has a very short half-life (e.g., 2 minutes) and requires a sustained effect, what is the most appropriate route of administration?
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Correct answer: Continuous intravenous infusion
Drugs with very short half-lives, like esmolol or nitroglycerin, are eliminated too quickly for intermittent dosing. A continuous infusion allows for minute-to-minute control of plasma levels and sustained therapeutic action.
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