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Drug Metabolism · Pharmacology

The term 'Vmax' in enzyme kinetics refers to:

  1. The total volume of the liver available for metabolism
  2. The dose of a drug required to kill 50% of a test population
  3. The drug concentration at which half of the enzyme sites are occupied
  4. The maximum rate of metabolism when the enzyme is fully saturated
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Correct answer: The maximum rate of metabolism when the enzyme is fully saturated

Vmax represents the highest rate of metabolism possible for a specific enzyme system. When drug concentrations are much higher than the enzyme's capacity (saturation), the reaction follows zero-order kinetics.

Difficulty: Medium Question 19 of 20

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