In the process of 'Redistribution', why does Thiopental have a very short duration of action following a single bolus injection?
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Correct answer: It moves from the brain into less-perfused tissues such as muscle and fat
Redistribution occurs when a highly lipid-soluble drug initially enters a highly perfused organ (the brain) and then slowly diffuses back into the blood to be taken up by bulky, less perfused tissues like skeletal muscle. This terminates its central effect before metabolism occurs.
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