Bioavailability · Pharmacology

What does the term bioavailability primarily refer to in pharmacology?

  1. The total amount of drug administered regardless of how much is absorbed
  2. The fraction of an administered drug that reaches systemic circulation unchanged
  3. The rate at which a drug is metabolized by liver enzymes after absorption
  4. The time required for a drug to be completely eliminated from the body after dosing
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Correct answer: The fraction of an administered drug that reaches systemic circulation unchanged

Bioavailability refers to the fraction of an administered drug dose that reaches the systemic circulation in an unchanged form. It reflects both the extent and sometimes the rate of drug absorption.

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