Which factor most commonly reduces the bioavailability of orally administered drugs?
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Correct answer: First-pass metabolism
First-pass metabolism occurs when drugs are metabolized in the liver before reaching systemic circulation. This reduces the amount of active drug available in the bloodstream.
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More Bioavailability questions
- Which pharmacokinetic parameter is most commonly used to estimate bioavailability?
- Which type of bioavailability compares two different formulations of the same drug?
- Absolute bioavailability is calculated by comparing a drug administered orally with which route?
- Which factor related to drug formulation can influence bioavailability?
- Which physiological factor may significantly affect oral drug bioavailability?
- Which property of a drug strongly influences its ability to cross biological membranes and affect bioavailability?