Proton Pump Inhibitors · Pharmacology

Which of the following is a symptom of Zollinger-Ellison Syndrome, for which PPIs are the treatment of choice?

  1. Inadequate gastric acid production
  2. Gastrin-secreting tumor causing severe peptic ulcers
  3. Autoimmune destruction of parietal cells
  4. Hypersecretion of insulin
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Correct answer: Gastrin-secreting tumor causing severe peptic ulcers

Zollinger-Ellison syndrome involves gastrinomas that cause massive acid production. PPIs are highly effective at controlling acid levels and healing the resulting refractory peptic ulcers in these patients.

Difficulty: Medium Question 14 of 20

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