Why does Diazepam have a much longer duration of action than its initial half-life suggests?

1. It binds irreversibly to the GABA-A receptor and cannot dissociate
2. It inhibits its own metabolism by suppressing hepatic CYP3A4 activity
3. It is converted into active metabolites with very long half-lives
4. It is excreted unchanged by the lungs over several days

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