Sedatives and Hypnotics · Pharmacology

The 'hangover effect' or morning-after grogginess is most pronounced with which type of hypnotics?

  1. Short-acting Z-drugs
  2. Long-acting benzodiazepines
  3. Melatonin receptor agonists
  4. Orexin antagonists
Show answer and explanation

Correct answer: Long-acting benzodiazepines

Drugs with long half-lives or active metabolites (like flurazepam or quazepam) tend to remain in the system at sedative levels well into the next day, causing impaired coordination and daytime sleepiness.

Difficulty: Medium Question 17 of 20

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