Local Anesthetics · Pharmacology

Which condition may reduce the effectiveness of local anesthetics?

  1. Well-perfused healthy tissue
  2. High oxygen levels
  3. Infected acidic tissue
  4. Normal pH tissue
Show answer and explanation

Correct answer: Infected acidic tissue

In infected tissues, the environment is often acidic. This reduces the amount of uncharged anesthetic that can penetrate nerve membranes, decreasing effectiveness.

Difficulty: Medium Question 17 of 20

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