General Anesthetics · Pharmacology

Which of the following describes the 'Second Gas Effect' associated with Nitrous Oxide?

  1. The metabolism of one gas within the liver accelerates the breakdown and clearance of another
  2. The rapid uptake of a large volume of one gas concentrates the second gas in the alveoli
  3. One gas prevents the cardiovascular side effects of another
  4. Two gases compete for the same receptor site in the brain
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Correct answer: The rapid uptake of a large volume of one gas concentrates the second gas in the alveoli

Nitrous oxide is given in high concentrations. As it is rapidly absorbed from the alveoli into the blood, the remaining gases (like Sevoflurane) are concentrated in a smaller volume, accelerating their uptake and induction.

Difficulty: Medium Question 11 of 20

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