Which of the following adverse effects is classically associated with long-term Phenytoin therapy?
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Correct answer: Gingival hyperplasia
Gingival hyperplasia (overgrowth of the gums) occurs in about 20% of patients on chronic Phenytoin. Other classic side effects include hirsutism, coarsening of facial features, and interference with folate metabolism leading to megaloblastic anemia.
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