Anticoagulants · Pharmacology

What is the specific reversal agent for the anticoagulant effects of Dabigatran?

  1. Protamine sulfate
  2. Andexanet alfa
  3. Idarucizumab (Praxbind)
  4. Phytomenadione (Vitamin K1)
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Correct answer: Idarucizumab (Praxbind)

Idarucizumab is a humanized monoclonal antibody fragment that binds specifically to dabigatran with much higher affinity than thrombin, immediately neutralizing its anticoagulant effect.

Difficulty: Medium Question 4 of 20

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