A patient on heparin therapy develops a sudden, severe drop in platelet count (over 50%). Which agent should be used as an alternative anticoagulant if Heparin-Induced Thrombocytopenia (HIT) is suspected?
Show answer and explanation
Correct answer: Argatroban
Argatroban is a direct thrombin inhibitor that does not cross-react with HIT antibodies. Low Molecular Weight Heparins like Enoxaparin must be avoided in HIT as they can worsen the prothrombotic state.
Keep practicing
More Anticoagulants questions
- What is the specific reversal agent for the anticoagulant effects of Dabigatran?
- Which of the following describes the mechanism of Rivaroxaban and Apixaban?
- Which Vitamin K-dependent clotting factor has the shortest half-life, leading to its early depletion during Warfarin initiation?
- What is the major disadvantage of Fondaparinux compared to Unfractionated Heparin?
- Why is 'bridging' with Heparin often required when starting a patient on Warfarin therapy?
- Protamine sulfate is used to neutralize the effects of Heparin. Which property of Protamine allows this interaction?