Which enzyme is responsible for the degradation of circulating catecholamines like Epinephrine in the liver and kidneys?
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Correct answer: Catechol-O-methyltransferase (COMT)
COMT and MAO are the two primary enzymes involved in the metabolism of catecholamines. COMT is especially important for metabolizing circulating (extraneuronal) catecholamines, whereas MAO is primarily located within neurons and the gut.
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