What is the chemical structural difference between catecholamines and non-catecholamines?
Show answer and explanation
Correct answer: Non-catecholamines lack the 3,4-dihydroxybenzene (catechol) ring
Catecholamines possess a catechol ring (benzene with two hydroxyl groups), making them substrates for COMT and giving them low oral bioavailability and short durations. Non-catecholamines lack these hydroxyl groups, making them resistant to COMT and often more effective when taken orally.
Keep practicing
More Sympathomimetics questions
- Which sympathetic effect is mediated by the Alpha-1 receptor in the eye?
- In the context of autonomic pharmacology, 'Tachyphylaxis' refers to:
- Which of the following describes the mechanism of action of 'mixed-acting' sympathomimetics like Ephedrine?
- Which of the following sympathomimetics is a selective Beta-2 agonist commonly used to treat acute bronchospasm?
- In the cardiovascular system, what is the primary effect of a low-dose Dopamine infusion (0.5-2 mcg/kg/min)?
- Which of the following is an indirect-acting sympathomimetic that acts primarily by inhibiting the Reuptake 1 (NET) transporter?