Phenylephrine causes a rise in blood pressure, which often results in a compensatory 'reflex bradycardia'. Which receptor is primarily responsible for the initial pressor response?
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Correct answer: Alpha-1
Phenylephrine is a selective Alpha-1 agonist that causes potent peripheral vasoconstriction. The resulting increase in systemic vascular resistance triggers the baroreceptor reflex, which increases vagal tone to slow the heart rate.
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