Organophosphate Toxicity · Pharmacology

The primary pharmacologic goal in treating organophosphate toxicity is to:

  1. Continuously increase synaptic acetylcholine levels to stimulate all receptor types
  2. Block acetylcholine effects and restore enzyme activity
  3. Suppress sympathetic output
  4. Enhance GABA transmission
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Correct answer: Block acetylcholine effects and restore enzyme activity

Treatment aims to block excess acetylcholine at receptors (with atropine) and restore acetylcholinesterase activity (with pralidoxime). This reduces life-threatening symptoms.

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