Organophosphate Toxicity · Pharmacology

Pralidoxime is effective in organophosphate poisoning because it:

  1. Blocks nicotinic receptors
  2. Reactivates acetylcholinesterase
  3. Inhibits acetylcholine release
  4. Enhances GABAergic inhibition in CNS
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Correct answer: Reactivates acetylcholinesterase

Pralidoxime reactivates acetylcholinesterase by removing the organophosphate from the enzyme if given before aging occurs. This restores normal neuromuscular function.

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