Which of the following is a GANGLIONIC blocker once used to treat hypertension but now rarely used due to widespread autonomic side effects?
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Correct answer: Mecamylamine
Mecamylamine blocks nicotinic (Nn) receptors at both sympathetic and parasympathetic ganglia. Because it shuts down the entire autonomic nervous system, it causes severe orthostatic hypotension, constipation, and blurred vision.
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