Cholinergic Antagonists · Pharmacology

Which of the following describes the primary mechanism of action of Atropine?

  1. Irreversible antagonism of nicotinic receptors
  2. Competitive antagonism of muscarinic receptors
  3. Non-competitive inhibition of acetylcholinesterase
  4. Activation of alpha-1 adrenergic receptors
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Correct answer: Competitive antagonism of muscarinic receptors

Atropine is a competitive antagonist that binds to muscarinic receptors, preventing acetylcholine from binding. This action blocks parasympathetic postganglionic impulses, leading to effects like tachycardia and decreased secretions.

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