Which of the following is a non-selective alpha-adrenergic antagonist that binds irreversibly to alpha-1 and alpha-2 receptors via covalent bonding?
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Correct answer: Phenoxybenzamine
Phenoxybenzamine is a non-competitive, irreversible antagonist. Because it forms a covalent bond with the receptor, the body must synthesize new receptors to overcome the blockade, resulting in a long duration of action.
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